阿斯利康携重磅研究，创连续七年亮相美国临床肿瘤学会(ASCO)全体大会纪录，进一步彰显重新定义乳腺癌治疗和改变胃癌治疗结局的雄心

2025-05-22 16:54 来源:阿斯利康

阿斯利康

    SERENA-6 研究的全体大会报告将聚焦用于晚期 HR 阳性乳腺癌一线治疗的新一代口服 SERD 药物 Camizestrant

    MATTERHORN 研究的全体大会报告将展示英飞凡用于早期胃和胃食管结合部腺癌的围手术期治疗方案

    DESTINY-Breast09 研究的专场口头报告将强调优赫得在 HER2 阳性转移性乳腺癌更前线治疗的潜力

    上海 2025年5月22日 /美通社/ -- 阿斯利康在2025年5月30日至6月3日召开的美国临床肿瘤学会（ASCO）上，凭借行业领先的多样化产品与管线布局的全新研究数据，进一步深化自身让癌症不再成为致死主因的雄心。

    会上将有超过80个摘要公布，其中涵盖20款已获得批准的药物和潜在新药，包括两项重磅研究的全体大会报告（plenary presentation），一项特别重磅研究摘要口头报告（late-breaking oral abstract session），以及19项口头报告。其中亮点包括：

    • SERENA-6 ：评估了Camizestrant与广泛获批的细胞周期蛋白依赖性激酶（CDK）4/6抑制剂联合，用于一线治疗激素受体（HR）阳性、HER2阴性且肿瘤出现ESR1突变的晚期乳腺癌患者的III期临床研究（Plenary #LBA4）。Camizestrant是在研的新一代选择性雌激素受体降解剂（SERD）和完全ER拮抗剂。这是首个在一线治疗中取得阳性结果的新一代口服SERD药物III期临床研究，也是Camizestrant的首个III期阳性结果。
    • MATTERHORN：评估了度伐利尤单抗联合FLOT化疗作为可切除的早期和局部晚期的胃和胃食管结合部腺癌（GEJ）患者围手术期治疗方案的III期研究（Plenary #LBA5）。
    • DESTINY-Breast09：评估德曲妥珠单抗联合帕妥珠单抗用于一线治疗HER2阳性转移性乳腺癌患者治疗获益的III期研究（口头报告摘要#LBA1008）。
    • DESTINY-Gastric04 ：评估了德曲妥珠单抗用于二线治疗HER2阳性不可切除和/或转移性胃和胃食管结合部腺癌患者的治疗获益的III期研究（#LBA4002）。
    • NeoADAURA：奥希替尼联合或不联合化疗作为新辅助治疗用于可切除的早期EGFR突变非小细胞肺癌（NSCLC）的III期临床研究（口头报告摘要#8001）。
    • TROPION-Lung02：Datroway联合帕博利珠单抗的联合或不联合铂类一线化疗治疗无驱动基因突变的晚期非小细胞肺癌的Ib期临床研究结果，基于计算病理学生物标志物分析（口头报告摘要#8501）。
    • KOMET：评估司美替尼治疗伴有症状性、无法手术的丛状神经纤维瘤的1型神经纤维瘤病成人患者的III期临床研究（快速口头摘要#3014）。

    阿斯利康全球执行副总裁、全球肿瘤研发负责人高书璨（ Susan Galbraith）表示："本次ASCO大会上公布的两项乳腺癌重磅研究数据将凸显我们在以创新药物和产品管线改变肿瘤治疗结局上所取得的进展。SERENA-6是首个采用循环肿瘤DNA检测指导治疗方案切换的一项关键III期临床研究，开创了这一技术在一线治疗中的应用，以延缓HR阳性、HER2阴性晚期乳腺癌的疾病进展。此外，DESTINY-Breast09研究评估了德曲妥珠单抗与帕妥珠单抗的联合治疗方案，这是十年来首次在HER2阳性转移性乳腺癌广泛患者群体中，证明疗效优于目前一线治疗标准方案的试验。"

    阿斯利康全球执行副总裁，全球肿瘤研发负责人Dave Fredrickson表示："MATTERHORN的研究数据证明，度伐利尤单抗作为胃和胃食管结合部腺癌患者围手术期的治疗方案，是我们将免疫疗法迁入癌症早期阶段治疗的成功例证，有望实现早期治愈的可能。这是阿斯利康连续第七年登上ASCO全体大会，这一非凡的里程碑彰显出我们在多个癌肿领域已建立行业领先的肿瘤产品组合和强大的研发管线。

    阿斯利康与第一三共联合开发和商业化德曲妥珠单抗与Datroway；与默沙东（默沙东是美国新泽西州罗威市默克公司的公司商号）联合开发和商业化司美替尼；与和黄医药合作开发和商业化赛沃替尼。

    阿斯利康在 2025 年 ASCO 大会期间的重要演讲 1

    主要作者

    摘要标题

    演示文稿详情 (CDT)

    抗体偶联药物

    Shitara, K

    Trastuzumab deruxtecan (T-
    DXd) vs ramucirumab (RAM) +
    paclitaxel (PTX) in second-line
    treatment of patients (pts) with
    human epidermal growth factor
    receptor 2-positive (HER2+)
    unresectable/metastatic gastric
    cancer (GC) or
    gastroesophageal junction
    adenocarcinoma (GEJA):
    Primary analysis of the
    randomized, phase 3
    DESTINY-Gastric04 study.

    Abstract #LBA4002

    Oral Abstract Session

    31 May 2025

    3:24pm

    Tolaney, SM

    Trastuzumab deruxtecan (T-
    DXd) + pertuzumab (P) vs
    taxane + trastuzumab +
    pertuzumab (THP) for first-line
    (1L) treatment of patients (pts)
    with human epidermal growth
    factor receptor 2–positive
    (HER2+) advanced/metastatic
    breast cancer (a/mBC): Interim
    results from DESTINY-Breast09.

    Abstract #LBA1008

    Oral Abstract Session

    2 June 2025

    7:30am

    Dent, R

    Exploratory biomarker analysis
    of trastuzumab deruxtecan (T-
    DXd) vs physician's choice of
    chemotherapy (TPC) in HER2-
    low/-ultralow, hormone
    receptor-positive (HR+)
    metastatic breast cancer (mBC)
    in DESTINY-Breast06 (DB-06).

    Abstract #1013

    Oral Abstract Session

    31 May 2025

    3:23pm

    Levy, BP

    TROPION-Lung02:
    Datopotamab deruxtecan
    (Dato-DXd) plus
    pembrolizumab (pembro) with
    or without platinum
    chemotherapy (Pt-CT) as first-
    line (1L) therapy for advanced
    non-small cell lung cancer (aNSCLC).

    Abstract #8501

    Oral Abstract Session

    1 June 2025

    8:12am

    Waqar, SN

    First-line (1L) datopotamab
    deruxtecan (Dato-DXd) +
    rilvegostomig in advanced or
    metastatic non-small cell lung
    cancer (a/mNSCLC): Results
    from TROPION-Lung04 (cohort 5).

    Abstract #8521

    Poster Session

    31 May 2025

    1:30pm

    肿瘤驱动因素和耐药性

    Turner, NC

    Camizestrant + CDK4/6
    inhibitor (CDK4/6i) for the
    treatment of emergent ESR1
    mutations during first-line (1L)
    endocrine-based therapy (ET)
    and ahead of disease
    progression in patients (pts)
    with HR+/HER2– advanced
    breast cancer (ABC): Phase 3,
    double-blind ctDNA-guided
    SERENA-6 trial.

    Abstract #LBA4

    Plenary Session

    1 June 2025

    2:41pm

    Lu, S

    Savolitinib (Savo) combined
    with osimertinib (osi) versus
    chemotherapy (chemo) in
    EGFR-mutant (EGFRm) and
    MET-amplification (METamp)
    advanced NSCLC after disease
    progression (PD) on EGFR
    tyrosine kinase inhibitor (TKI):
    Results from a randomized
    phase 3 SACHI study.

    Abstract #LBA8505

    Oral Abstract Session

    1 June 2025

    9:48am

    Levy, BP

    Efficacy and CNS results from
    a randomized subset of the
    phase 2 SAVANNAH study
    comparing savolitinib (savo) +
    osimertinib (osi) combination
    with savo + placebo (PBO).

    Abstract #8513

    Rapid Oral Abstract Session

    2 June 2025

    8:06am

    Chaft JE

    Neoadjuvant (neoadj)
    osimertinib (osi) ±
    chemotherapy (CT) vs CT
    alone in resectable (R)
    epidermal growth factor
    receptor-mutated (EGFRm)
    NSCLC: NeoADAURA.

    Abstract #8001

    Oral Abstract Session

    2 June 2025

    3:12pm

    免疫肿瘤学与双特异性抗体

    Janjigian, YY

    Event-free survival in
    MATTERHORN: a randomized,
    phase 3 study of durvalumab
    plus 5-fluorouracil, leucovorin,
    oxaliplatin, and docetaxel
    chemotherapy (FLOT) in
    resectable
    gastric/gastroesophageal
    junction cancer (GC/GEJC).

    Abstract #LBA5

    Plenary Session

    1 June 2025

    3:13pm

    Powles, T

    Circulating tumor DNA (ctDNA)
    in patients with muscle-invasive
    bladder cancer (MIBC) who
    received perioperative
    durvalumab (D) in NIAGARA

    Abstract #4503

    Oral Abstract Session

    1 June 2025

    10:45am

    Reck, M

    Associations of post-surgical
    MRD status with neoadjuvant
    ctDNA dynamics, genomic
    mutations, and clinical
    outcomes in patients with
    resectable NSCLC (R-NSCLC)
    from the phase 3 AEGEAN trial.

    Abstract #8009

    Rapid Oral Abstract Session

    1 June 2025

    4:30pm

    Barbie, DA

    Clinical and molecular
    characteristics of early
    progressors (EPs) and long
    -term progression-free survivors
    (LTPs) from the phase 3
    ADRIATIC trial of
    consolidation durvalumab (D) vs placebo (P)
    after concurrent
    chemoradiotherapy (cCRT) in
    limited-stage small-cell lung
    cancer (LS-SCLC).

    Abstract #8014

    Rapid Oral Abstract Session

    1 June 2025

    5:12pm

    Mayadev, J

    Ultrasensitive detection and
    tracking of circulating tumor
    DNA (ctDNA) and association
    with relapse and survival in
    locally advanced cervical
    cancer (LACC): Phase 3
    CALLA trial analyses.

    Abstract #5502

    Oral Abstract Session

    2 June 2025

    8:48am

    Westin, SN

    Durvalumab plus
    carboplatin/paclitaxel followed
    by durvalumab with or without
    olaparib as first-line treatment
    for endometrial cancer:
    Longitudinal changes in
    circulating tumor DNA.

    Abstract #5512

    Rapid Oral Abstract Session

    3 June 2025

    8:30am

    Erinjeri, JP

    Outcomes by baseline tumor
    burden using the 6-and-12
    score in EMERALD-1: a phase
    3 study of durvalumab (D) ±
    bevacizumab (B) with transarterial
    chemoembolization (TACE) in
    embolization-eligible
    unresectable hepatocellular
    carcinoma (uHCC).

    Abstract #4083
    Poster Session

    31 May 2025

    9:00am

    Cascone, T

    Neoadjuvant durvalumab (D) +
    chemotherapy (CT) + novel
    anticancer agents and adjuvant
    D ± novel agents in resectable
    non-small-cell lung cancer
    (NSCLC): Updated outcomes
    from NeoCOAST-2.

    Abstract #8046

    Poster Session

    31 May 2025

    1:30pm

    Zhou, J

    First-line rilvegostomig (rilve)
    plus chemotherapy (CTx) in
    advanced biliary tract cancer
    (BTC): Primary analysis of
    GEMINI-Hepatobiliary substudy
    2 Cohort A.

    Abstract #4080

    Poster Session

    31 May 2025

    9:00am

    Xu, R

    ARTEMIDE-Gastric01: a phase
    3 randomized study of
    rilvegostomig with
    fluoropyrimidine and
    trastuzumab deruxtecan (T-
    DXd) as first-line (1L) treatment
    for locally advanced or
    metastatic HER2-positive
    gastric or gastroesophageal
    junction cancer (GC/GEJC).

    Abstract #TPS4204

    Poster Session

    31 May 2025

    9:00am

    Mathias, C

    ARTEMIDE-Lung03: a phase 3,
    randomized, double-blind,
    multicenter, global study of
    rilvegostomig or
    pembrolizumab in combination
    with platinum-based
    chemotherapy as first-line
    treatment for patients with
    metastatic non-squamous non-
    small-cell lung cancer whose
    tumors express PD-L1.

    Abstract #TPS8653

    Poster Session

    31 May 2025

    1:30pm

    细胞疗法

    Yoo, C

    RHEA-1: First-in-human (FIH)
    study of AZD9793, a first-in-
    class CD8-guided T cell-
    engager (TCE) for glypican-3-
    positive (GPC3+) advanced or
    metastatic hepatocellular
    carcinoma (HCC).

    Abstract #TPS4215

    Poster Session

    31 May 2025

    9:00am

    Kim, TM

    Safety and Efficacy of
    AZD0486, a CD19xCD3 T-cell
    Engager, in Relapsed or
    Refractory Diffuse Large B-cell
    Lymphoma.

    Abstract #7046
    Poster Session

    1 June 2025

    9:00am

    Shadman, M

    TITANium: An open-label,
    global multicenter Phase 1/2
    study of AZD5492, a first-in-
    class subcutaneous CD8-
    guided tri-specific T-cell
    engager (TCE), in patients (pts)
    with relapsed or refractory (r/r)
    B-cell malignancies.

    Abstract #TPS7091

    Poster Session

    1 June 2025

    9:00am

    Le Gouill, S

    SOUNDTRACK-E: A Phase 1/2
    Open-label Multicenter Study to
    Evaluate the Safety and
    Efficacy of AZD0486
    Monotherapy or Combination
    Therapy in Patients With
    Mature B-cell Malignancies.

    Abstract #TPS7083

    Poster Session

    1 June 2025

    9:00am

    罕见病药物

    Chen, AP

    Efficacy and safety of
    selumetinib in adults with
    neurofibromatosis type 1 (NF1)
    and symptomatic, inoperable
    plexiform neurofibroma (PN):
    Primary analysis of KOMET
    (NCT04924608), a Phase 3,
    international, randomized,
    placebo-controlled study.

    Abstract #3014

    Rapid Oral Abstract Session

    2 June 2025

    8:00am

    1 阿斯利康在2025年ASCO大会将公布超过80个摘要，涵盖其产品和管线中的分子药物

    关于阿斯利康肿瘤领域的研究

    阿斯利康正引领着肿瘤领域的一场革命，致力提供多元化的肿瘤治疗方案，以科学探索肿瘤领域的复杂性，发现、研发并向患者提供改变生命的药物。

    阿斯利康专注于最具挑战性的肿瘤疾病，通过持续不断的创新，阿斯利康已经建立了行业领先的多元化的产品组合和管线，持续推动医疗实践变革，改变患者体验。

    阿斯利康以期重新定义癌症治疗并在未来攻克癌症。

    关于阿斯利康

    阿斯利康（LSE/STO/Nasdaq: AZN）是一家科学至上的全球生物制药企业，专注于研发、生产及营销处方类药品，重点关注肿瘤、罕见病以及包括心血管肾脏及代谢、呼吸及免疫在内的生物制药等领域。阿斯利康全球总部位于英国剑桥，业务遍布超过125个国家，创新药物惠及全球数百万患者。更多信息，请访问www.astrazeneca.com。

    关于阿斯利康中国

    阿斯利康自1993年进入中国以来，专注中国患者需求最迫切的治疗领域，包括肿瘤、心血管、肾脏、代谢、呼吸、消化、罕见病、疫苗抗体及自体免疫等，已将40多款创新药物带到中国。阿斯利康中国总部位于上海，并在上海和北京设立全球战略研发中心，在北京、广州、杭州、成都、青岛设立区域总部，在无锡、泰州、青岛建立全球生产供应基地，向全球70多个市场输送优质创新药品。

    声明：本文研究中涉及的多种药品用法尚未在中国获批适应症，阿斯利康不推荐任何未被批准的药品使用。

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